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bioRxiv · 10.1101/2025.03.07.642094

Predicting cognition using estimated structural and functional connectivity networks and artificial intelligence in multiple sclerosis

Abstract

BackgroundOur prior work demonstrated that estimated structural and functional connectomes (eSC and eFC) generated using multiple sclerosis (MS) lesion masks and artificial intelligence (AI) models can predict disability as effectively as SC and FC derived from diffusion and functional MRI in MS. The goal of this study was to assess the ability of eSC and eFC in predicting baseline and 4-year follow-up cognition in MS patients. MethodsOne hundred seventy-one MS patients (age: 42.67{+/-}10.41, 74% females) were included. The Symbol Digit Modalities Test (SDMT), California Verbal Learning Test (CVLT), and Brief Visuospatial Memory Test (BVMT) were used to assess cognition. The Network Modification tool was performed to estimate SC, which was then used as an input to Krakencoder, an encoder-decoder model, to estimate FC. Ridge regression was performed to predict cognition using regional eSC and eFC, along with demographics and clinical information as well as conventional MRI metrics. Baseline cognition was added to the models that were used to predict the follow-up cognition. Spearmans correlation (r) was used to assess the prediction accuracy. ResultsThe highest accuracy was obtained when predicting follow-up SDMT using regional eSC or eFC (median r=0.58 for eSC and r=0.56 for eFC). Decreased eSC and eFC in the cerebellum and increased eFC in the default mode network were associated with lower follow-up SDMT scores. Baseline SDMT, clinical subtype, and age were the most important non-connectome metrics in predicting follow-up SDMT. ConclusionsOur findings demonstrate that eSC and eFC derived from clinically acquired MRI and AI models can effectively predict cognition. The use of lesion-based estimates of connectome disruptions may potentially improve cognition-related individualized treatment planning.

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BibTeXRIS

Tozlu, C., Ong, D., Piccirillo, C., Schwartz, H., Jaywant, A., Nguyen, T., Jamison, K. W., Gauthier, S. A., Kuceyeski, A.. 2025-03-11. Predicting cognition using estimated structural and functional connectivity networks and artificial intelligence in multiple sclerosis. https://doi.org/10.1101/2025.03.07.642094

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