Motivational control is implemented by a cingulo-prefrontal pathway

Gandaux, C.; Sallet, J.; Amiez, C.; Autran-Clavagnier, D.; Morel-Latour, V.; Goussi-Denjean, C.; Fontanier, V.; Misery, P.; Lamy, C.; Lamberton, F.; Lavigne, M.; Kremer, E. J.; Wislon, C. R. E.; Procyk, E.

doi:10.1101/2025.02.11.637635

bioRxiv · 10.1101/2025.02.11.637635

Motivational control is implemented by a cingulo-prefrontal pathway

Gandaux, C.·Sallet, J.·Amiez, C.·Autran-Clavagnier, D.·Morel-Latour, V.·Goussi-Denjean, C.·Fontanier, V.·Misery, P.·Lamy, C.·Lamberton, F.·Lavigne, M.·Kremer, E. J.·Wislon, C. R. E.·Procyk, E.

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Abstract

The neuronal connections between the midcingulate cortex (MCC) and the dorsolateral prefrontal cortex (dlPFC) are associated with multiple cognitive functions, including rapid and long-term adaptive processes. Here we show that DREADD-mediated activation of MCC to dlPFC projection in macaques led to increased engagement in a foraging task, but did not alter their trial-to-trial adaptive strategy. We conclude that a critical role for MCC-dlPFC pathway is in the temporally extended control of behaviour rather than in rapid adaptation.

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Gandaux, C., Sallet, J., Amiez, C., Autran-Clavagnier, D., Morel-Latour, V., Goussi-Denjean, C., Fontanier, V., Misery, P., Lamy, C., Lamberton, F., Lavigne, M., Kremer, E. J., Wislon, C. R. E., Procyk, E.. 2025-02-12. Motivational control is implemented by a cingulo-prefrontal pathway. https://doi.org/10.1101/2025.02.11.637635

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