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bioRxiv · 10.1101/2025.02.10.637397

Topological Analysis of Vascular Networks: A Proof-of-Concept Study in Cerebral Angiography

Tozzi, A.
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Abstract

The application of topological methods to cerebral angiography may provide a robust mathematical framework for analyzing cerebrovascular structures at multiple scales. In this proof-of concept study, we explored the use of algebraic and differential topology to characterize structural integrity, connectivity, flow dynamics and hierarchical organization of cerebral vascular networks. Through a hierarchical approach, we examined the topology from general to local, capturing macroscopic vascular organization down to individual vessel bifurcations. By leveraging key theorems, we assessed various aspects of topological analysis, including evaluation of total features, transition from total to local features, evaluation of local features, transition from local to total features, interaction between total and local features. These steps enable the analysis of the global connectivity of the vascular network, the detection of regional clusters and the identification of critical junctions at a local scale. A computational approach was developed to extract mathematical skeletons from angiographic images, constructing graph-based representations to study connectivity and homotopy equivalence. The Fourier decomposition of the vascular structures revealed dominant periodic patterns, indicative of structural stability and redundancy in the blood supply. Moreover, Betti number computations quantified vascular loops and branches, offering insights into collateral circulation potential. Our findings demonstrate that topological invariants can serve as diagnostic biomarkers for cerebrovascular diseases, including aneurysm susceptibility and ischemic risk assessment. This interdisciplinary methodology bridges mathematical topology with medical imaging, offering a novel lens for cerebrovascular analysis. Future work will integrate persistent homology and machine learning techniques for automated vascular topology classification.

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Tozzi, A.. 2025-02-13. Topological Analysis of Vascular Networks: A Proof-of-Concept Study in Cerebral Angiography. https://doi.org/10.1101/2025.02.10.637397

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