Cross-Species Biomechanical Determinants of Shape Diversity

Bailleul, R.; Cuny, N.; Khoromoskaia, D.; Basu, S.; Bergamini, G.; Cucurachi, P.; Rupp, S.; Guse, A.; Curantz, C.; Swinhoe, N.; Cleves, P.; Craggs, J.; Fujita, S.; Nakajima, Y.; Steenbergen, P.; Diz-Munoz, A.; Salbreux, G.; Ikmi, A.

doi:10.1101/2025.02.07.637025

bioRxiv · 10.1101/2025.02.07.637025

Cross-Species Biomechanical Determinants of Shape Diversity

Bailleul, R.·Cuny, N.·Khoromoskaia, D.·Basu, S.·Bergamini, G.·Cucurachi, P.·Rupp, S.·Guse, A.·Curantz, C.·Swinhoe, N.·Cleves, P.·Craggs, J.·Fujita, S.·Nakajima, Y.·Steenbergen, P.·Diz-Munoz, A.·Salbreux, G.·Ikmi, A.

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Abstract

How complex molecular mechanisms translate into diverse multicellular shapes remains unclear. By leveraging the bi-layered architecture of six cnidarian species that diverged 500 million years ago, we show that modularity in supracellular mechanics governs larval shape diversity. Using active surface theory, quantitative imaging, and an inducible genetic system, we identify species-specific variations in three biomechanical modules. Basally aligned stress fibers drive axial elongation, while oral geometry and aboral rigidity define shape polarity. Remarkably, manipulating these modules transforms one species shape into another, demonstrating the causal relationship between module variation and shape diversity. Our analysis also uncovers instances of mechanical redundancies, where distinct module combinations generate similar shapes. These findings provide a general framework for how molecular complexity funnels into mesoscale mechanical determinants shaping morphological diversity.

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Bailleul, R., Cuny, N., Khoromoskaia, D., Basu, S., Bergamini, G., Cucurachi, P., Rupp, S., Guse, A., Curantz, C., Swinhoe, N., Cleves, P., Craggs, J., Fujita, S., Nakajima, Y., Steenbergen, P., Diz-Munoz, A., Salbreux, G., Ikmi, A.. 2025-02-08. Cross-Species Biomechanical Determinants of Shape Diversity. https://doi.org/10.1101/2025.02.07.637025

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