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bioRxiv · 10.1101/2025.02.06.636959

Cerebellar climbing fibers convey perceptual choice during decision-making

Yiu, T. L.·Wilson, E. A.·Yahiro, T.·Ma, L.·Qin, M.·Zhong, H.
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Abstract

Cerebellar climbing fibers are thought to signal reward prediction errors in non-motor functions. By imaging postsynaptic responses of climbing fibers onto mouse Purkinje cell dendrites during auditory discrimination, we found that climbing fibers in crus I can encode cue identities or perceptual choices. These responses were reshaped by reversal learning. Optogenetic perturbation of climbing fiber activity impaired discrimination. These results suggest a feedforward role of climbing fibers in perceptual decision-making.

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Yiu, T. L., Wilson, E. A., Yahiro, T., Ma, L., Qin, M., Zhong, H.. 2025-02-08. Cerebellar climbing fibers convey perceptual choice during decision-making. https://doi.org/10.1101/2025.02.06.636959

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