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bioRxiv · 10.1101/2025.02.06.636950

Pan-cell type continuous chromatin state annotation of all IHEC epigenomes

Daneshpajouh, H.·Moghul, I.·Wiese, K. C.·Libbrecht, M. W.
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Abstract

The International Human Epigenome Consortium has generated thousands of epigenomic datasets that mea-sure various biochemical activities in the genome, including transcription factor binding, histone modification, and DNA accessibility. Currently, the predominant methods for integrating these datasets to annotate regu-latory elements are segmentation and genome annotation (SAGA) algorithms. The majority of annotations by these methods are cell type-specific. However, as the number of profiled cell types has grown into the thousands, using thousands of cell type-specific chromatin state annotations proves undesirable for many applications. Here, we present a pan-cell type annotation that summarizes all IHEC epigenomes using the recently-developed method, epigenome-ssm.

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Daneshpajouh, H., Moghul, I., Wiese, K. C., Libbrecht, M. W.. 2025-02-08. Pan-cell type continuous chromatin state annotation of all IHEC epigenomes. https://doi.org/10.1101/2025.02.06.636950

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