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bioRxiv · 10.1101/2025.02.05.636744

Activity-Dependent Changes in Ion Channel Voltage-Dependence Influence the Activity Patterns Targeted by Neurons

Mondal, Y.·Calabrese, R. L.·Marder, E.
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Abstract

Neurons can maintain stable activity profiles over their lifetimes despite ion channel turnover over minutes to weeks. Neuronal activity is also influenced by regulating the voltage-dependence of ion channels. How do these two forms of plasticity work together to maintain a stable activity profile? We augment a classical model of activity-dependent ion channel density regulation with a mechanism that adjusts channel voltage-dependence based on activity. These findings reveal that the timescale of these mechanisms shape the specific electrical activity patterns that achieve a target activity profile. Moreover, alterations in channel voltage-dependence can impact a neurons ability to recover from perturbations. These results highlight a potentially distinct role for activity-dependent regulation of channel voltage-dependence in maintaining stable neuronal activity profiles.

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Mondal, Y., Calabrese, R. L., Marder, E.. 2025-02-10. Activity-Dependent Changes in Ion Channel Voltage-Dependence Influence the Activity Patterns Targeted by Neurons. https://doi.org/10.1101/2025.02.05.636744

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