Repurposing Regulatory Toxicology Safety Data to Identify Potential Pro-Longevity Substances

Miwa, S.; Kucheryavenko, O.; Herrmann, K.; Saunter, C.; Raimundo, A.; Weinkove, D.; Niemann, L.; von Zglinicki, T.

doi:10.1101/2025.01.30.635304

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bioRxiv · 10.1101/2025.01.30.635304

Repurposing Regulatory Toxicology Safety Data to Identify Potential Pro-Longevity Substances

Miwa, S.·Kucheryavenko, O.·Herrmann, K.·Saunter, C.·Raimundo, A.·Weinkove, D.·Niemann, L.·von Zglinicki, T.

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Abstract

The repurposing of existing biosafety datasets offers unique opportunities in biomedical research. Here, we demonstrate how pesticide toxicity data, which include long-term survival studies in mammalian models, can be harnessed to uncover potential drug candidates or drug targets that can improve survival. We show that these substances frequently affect mitochondrial bioenergetics and that they can improve animal healthspan.

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Miwa, S., Kucheryavenko, O., Herrmann, K., Saunter, C., Raimundo, A., Weinkove, D., Niemann, L., von Zglinicki, T.. 2025-02-03. Repurposing Regulatory Toxicology Safety Data to Identify Potential Pro-Longevity Substances. https://doi.org/10.1101/2025.01.30.635304

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