Clinical and Genetic Determinants of Glioblastoma Multiforme Survival: A Retrospective Analysis

Gutierrez-Arroyo, J.; Gallego-Porcar, P.; Carbonell-Martinez, E.; Gonzalez-Bonet, L.; Ibanez, M. V.; Diaz-Ruiz, M.; Caballero-Arzapalo, H.; Soto, A.; Garcia-Oriola, G.; Borras-Moreno, J. M.; Martinez-Cadenas, C.; Marques-Torrejon, M. A.

doi:10.1101/2025.01.23.634459

bioRxiv · 10.1101/2025.01.23.634459

Clinical and Genetic Determinants of Glioblastoma Multiforme Survival: A Retrospective Analysis

Gutierrez-Arroyo, J.·Gallego-Porcar, P.·Carbonell-Martinez, E.·Gonzalez-Bonet, L.·Ibanez, M. V.·Diaz-Ruiz, M.·Caballero-Arzapalo, H.·Soto, A.·Garcia-Oriola, G.·Borras-Moreno, J. M.·Martinez-Cadenas, C.·Marques-Torrejon, M. A.

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Abstract

Glioblastoma, the most aggressive primary brain tumour in adults, has a poor prognosis and limited survival despite advances in treatment. This study analysed 61 patients with glioblastoma multiforme treated at the General University Hospital of Castellon, Spain, focusing on clinical, tumour-specific and genetic factors influencing disease outcome. Variables included age, sex, BMI, extent of surgical resection, and use of radiotherapy or chemotherapy. Tumour characteristics assessed included location, size, proximity to the ventricular system and surgical approach. Genetic mutations in the IDH, EGFR, TP53 and CDKN2A genes were also analysed. Kaplan-Meier analysis was used to assess the impact of these factors on overall survival and progression-free survival. A significant finding was the strong association between surgical approach, tumour proximity to the ventricular system and survival: patients with tumours closer to the ventricles had significantly shorter survival, highlighting the critical role of spatial tumour characteristics in glioblastoma multiforme outcomes. These results suggest that integrating clinical, genetic and spatial tumour data into personalised treatment approaches could improve prognosis. Understanding these factors is critical to developing more effective strategies to meet the challenges of this aggressive and complex disease.

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Gutierrez-Arroyo, J., Gallego-Porcar, P., Carbonell-Martinez, E., Gonzalez-Bonet, L., Ibanez, M. V., Diaz-Ruiz, M., Caballero-Arzapalo, H., Soto, A., Garcia-Oriola, G., Borras-Moreno, J. M., Martinez-Cadenas, C., Marques-Torrejon, M. A.. 2025-01-26. Clinical and Genetic Determinants of Glioblastoma Multiforme Survival: A Retrospective Analysis. https://doi.org/10.1101/2025.01.23.634459

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