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bioRxiv · 10.1101/2025.01.23.634446

Inverse hourglass pattern of conservation in rodent molar development.

Abstract

Although it is well established that certain stages of development are more conserved than others, the reasons for this phenomenon remain largely unknown. We study molecular conservation in the development of an organ, the molar, by comparing the temporal profiles of expression in mice and hamsters. We find that molar development is characterized by a rarely observed pattern of conservation of expression level and coding sequences forming an inverse hourglass, with more conservation at the beginning and end of morphogenesis than at intermediate stages. As the development of the rodent molar is well described, we were able to link this pattern to the properties of the expressed genes and the activity of different developmental processes. Early and late stages mobilize different sets of pleiotropic genes, cell division for bud growth and secretion for tooth mineralization. The particularities of dental morphogenesis and homeostasis, with the degradation of certain tissues at the end of development and the hosting of immune cells, as well as heterochronies linked to adaptations, also probably contribute to the pattern. Our study of the different actors explains the inverted hourglass of molars by a combination of processes intrinsic to the teeth, and by negative and positive selection which is mostly extrinsic to the teeth. This is likely translatable to explain molecular conservation patterns in many other biological systems.

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Ganofsky, J., Estevez-Villar, M., Mouginot, M., Moretti, S., Nyamari, M., Robinson-Rechavi, M., Semon, M., Pantalacci, S.. 2025-01-23. Inverse hourglass pattern of conservation in rodent molar development.. https://doi.org/10.1101/2025.01.23.634446

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