Foundational Architecture Enabling Federated Learning for Training Space Biomedical Machine Learning Models between the International Space Station and Earth

Casaletto, J. A.; Foley, P.; Fernandez, M.; Sanders, L. M.; Scott, R. T.; Ranjan, S.; Jain, S.; Haynes, N.; Boerma, M.; Costes, S. V.; Mackintosh, G.

doi:10.1101/2025.01.14.633017

bioRxiv · 10.1101/2025.01.14.633017

Foundational Architecture Enabling Federated Learning for Training Space Biomedical Machine Learning Models between the International Space Station and Earth

Casaletto, J. A.·Foley, P.·Fernandez, M.·Sanders, L. M.·Scott, R. T.·Ranjan, S.·Jain, S.·Haynes, N.·Boerma, M.·Costes, S. V.·Mackintosh, G.

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Abstract

The public and commercial space industries are planning longer duration and more distant space missions, including the establishment of a habitable lunar base and crewed missions to Mars. To support Earth-independent scientific and medical operations, such missions can leverage artificial intelligence and machine learning models to assist with crew healthcare, spacecraft maintenance, and other critical tasks. However, transferring large volumes of data between Earth and space for model development consumes valuable bandwidth, is vulnerable to communication disruptions, and may compromise crew safety and data privacy. Federated learning enables model training while keeping data in situ and only transferring model parameters. In this work, we present a flexible, resilient federated learning framework that provides the secure transmission of model updates between Earth and the International Space Station. On March 15, 2024, this framework pioneered the deployment of federated learning in a spaceflight setting, training classifier models between Earth and the ISS using both real biomedical research data and synthetically generated data.

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Casaletto, J. A., Foley, P., Fernandez, M., Sanders, L. M., Scott, R. T., Ranjan, S., Jain, S., Haynes, N., Boerma, M., Costes, S. V., Mackintosh, G.. 2025-01-19. Foundational Architecture Enabling Federated Learning for Training Space Biomedical Machine Learning Models between the International Space Station and Earth. https://doi.org/10.1101/2025.01.14.633017

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