Specialized response of default mode subnetworks and multiple-demand regions to transitions of person, place and time

Zhou, A. X.; Duncan, J.; Mitchell, D. J.

doi:10.1101/2025.01.14.631412

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bioRxiv · 10.1101/2025.01.14.631412

Specialized response of default mode subnetworks and multiple-demand regions to transitions of person, place and time

Zhou, A. X.·Duncan, J.·Mitchell, D. J.

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Abstract

This study used functional MRI data from the StudyForrest dataset to investigate the role of subnetworks of the default mode network (DMN) during naturalistic stimulus transitions of different types and magnitudes. We found distinct activation profiles within the DMN: the dmPFC subnetwork was specifically associated with character and location transitions, the MTL subnetwork preferred location and temporal transitions, while the Core DMN subnetwork responded to all three transition types. The multiple-demand network instead responded selectively to temporal transitions. These distinct response profiles appeared largely invariant to the semantic distance implied by the transitions. All subnetworks also responded significantly, and in a graded manner, to subjective event boundaries. Results suggest specific roles of the DMN subnetworks in perceiving and segmenting naturalistic events, supporting the view that DMN subnetworks cooperate in interpreting continuous external events and maintaining an updated contextual model of the world.

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Zhou, A. X., Duncan, J., Mitchell, D. J.. 2025-01-14. Specialized response of default mode subnetworks and multiple-demand regions to transitions of person, place and time. https://doi.org/10.1101/2025.01.14.631412

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