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bioRxiv · 10.1101/2024.12.30.630822

Personalized cue-reactive delta-theta oscillations guide deep brain stimulation for opioid use disorder

Qiu, L.·Nho, Y.·Seilheimer, R. L.·Kim, M. J.·Tufanoglu, A.·WILLIAMS, N.·Wexler, A.·David, O.·Katherine, S. W.·Pesaran, B.·Evins, A. E.·Richardson, M.·Childress, A. R.·Halpern, C. H.
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Abstract

Abstract / SummarySubstance use disorder (SUD) is a significant public health concern, with over 30% of the affected population not responding to available treatments. Severe SUD is characterized by drug-cue reactivity that has been reported to predict treatment-failure. We leveraged this pathophysiological feature to optimize deep brain stimulation (DBS) of the nucleus accumbens region (NAc) in an adult with SUD. A personalized drug cue-reactivity task was administered while recording NAc region electrophysiology from a lead externalized for clinical purposes. We identified a drug cue-evoked signal in the ventral NAc associated with intensification of opioid-related cravings, which attenuated subsequent to stimulation delivered to the same area. DBS was then programmed to engage this focal region, which resulted in sustained suppression of drug-related cravings. This finding heralds the potential for personalized strategies to optimize DBS for SUD.

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Qiu, L., Nho, Y., Seilheimer, R. L., Kim, M. J., Tufanoglu, A., WILLIAMS, N., Wexler, A., David, O., Katherine, S. W., Pesaran, B., Evins, A. E., Richardson, M., Childress, A. R., Halpern, C. H.. 2024-12-31. Personalized cue-reactive delta-theta oscillations guide deep brain stimulation for opioid use disorder. https://doi.org/10.1101/2024.12.30.630822

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