Effortful control and cortical brain structure in 5-year-old children: findings from the FinnBrain birth cohort study

Frantti, M.; Tuulari, J. J.; Nolvi, S.; Nordenswan, E.; Copeland, A.; Kumpulainen, V.; Silver, E.; Merisaari, H.; Saukko, E.; Kataja, E.-L.; Korja, R.; Karlsson, L.; Karlsson, H.; Pulli, E. P.

doi:10.1101/2024.12.21.629905

bioRxiv · 10.1101/2024.12.21.629905

Effortful control and cortical brain structure in 5-year-old children: findings from the FinnBrain birth cohort study

Frantti, M.·Tuulari, J. J.·Nolvi, S.·Nordenswan, E.·Copeland, A.·Kumpulainen, V.·Silver, E.·Merisaari, H.·Saukko, E.·Kataja, E.-L.·Korja, R.·Karlsson, L.·Karlsson, H.·Pulli, E. P.

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Abstract

The aim of this study was to explore the associations between an aspect of self-regulation (SR), effortful control (EC), and cortical brain structure in 5-year-old children. Efficient EC is a predictor of many attributes and important outcomes in life, such as social-emotional functioning, psychiatric and somatic health, finance, and criminal activity. The early brain correlates of EC are not widely studied, while a better understanding of them would aid in recognizing individuals at risk for maladaptive outcomes. Participants (N = 155) were a part of the FinnBrain Birth Cohort Study in Finland. T1-weighted brain magnetic resonance images were processed using FreeSurfer. The data was statistically analysed with a vertex-wise general linear model. At the age of 5 years, EC and its subscales, Attentional focusing, Inhibitory control (INH), Low intensity pleasure (LIP) and perceptual sensitivity, were assessed via parental report using The Childrens Behaviour Questionnaire. We found positive associations between overall EC and cortical volume in the left superior parietal region and in the right inferior temporal region. We also found positive associations between EC and surface area on the left hemisphere in the superior parietal region. The findings were driven by the EC subscales of INH and LIP with INH linking positively with left surface area and volume, and LIP linking with left cortical volume. We extended the previous literature by shedding light on early structural brain correlates of EC in a large sample of typically developing 5-year-olds. The results differed significantly from previous findings in older children, highlighting the need for longitudinal studies to better understand the neural underpinnings of SR throughout development.

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Frantti, M., Tuulari, J. J., Nolvi, S., Nordenswan, E., Copeland, A., Kumpulainen, V., Silver, E., Merisaari, H., Saukko, E., Kataja, E.-L., Korja, R., Karlsson, L., Karlsson, H., Pulli, E. P.. 2024-12-21. Effortful control and cortical brain structure in 5-year-old children: findings from the FinnBrain birth cohort study. https://doi.org/10.1101/2024.12.21.629905

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