Peptide Information Compression Technology (PICT): A New Frontier in Therapeutic Peptide Discovery

Wang, H.; Wang, Z.-Y.; Jiang, W.-M.; Wang, Q.-Q.; Miao, L.; Wang, D.; Wang, H.-T.; Tung, S.-F.; Yang, J.-R.; Yang, B.; Liang, X.-B.; Li, Z.-W.; Wang, X.-P.; Zou, S.; He, F.; Guo, X.-T.; Yan, Y.; Xu, K.-M.; Wang, X.-Q.; Wang, X.-B.; Liu, H.-Q.; Li, X.-Q.

doi:10.1101/2024.12.10.627447

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bioRxiv · 10.1101/2024.12.10.627447

Peptide Information Compression Technology (PICT): A New Frontier in Therapeutic Peptide Discovery

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Abstract

Therapeutic peptides hold tremendous market potential, yet the discovery methods for active peptides lag considerably behind those for small molecules and biological macromolecule drugs. Due to their respective limitations, traditional peptide compound synthesis and display libraries fail to meet the growing demands of the peptide drug market. Here, we introduce a novel Peptide Information Compression Technology (PICT) and, based on this technology, a large-scale physical peptide library and its accompanying high-throughput screening (HTS) platform. By screening for inhibitors of TSLP/TSLPR/IL7R and antagonists of MC3R at both the molecular and cellular levels, we have identified active molecules in the single-digital micromolar and nanomolar ranges, respectively. This demonstrates the immense application value of Peptide Information Compression Technology in the efficient discovery of peptide drugs.

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Wang, H., Wang, Z.-Y., Jiang, W.-M., Wang, Q.-Q., Miao, L., Wang, D., Wang, H.-T., Tung, S.-F., Yang, J.-R., Yang, B., Liang, X.-B., Li, Z.-W., Wang, X.-P., Zou, S., He, F., Guo, X.-T., Yan, Y., Xu, K.-M., Wang, X.-Q., Wang, X.-B., Liu, H.-Q., Li, X.-Q.. 2024-12-13. Peptide Information Compression Technology (PICT): A New Frontier in Therapeutic Peptide Discovery. https://doi.org/10.1101/2024.12.10.627447

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