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bioRxiv · 10.1101/2024.12.09.627512

Changes in urinary proteome of rats before and after noise exposure

Yang, M.·Zhao, C.·Gao, Y.
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Abstract

This study established an acute noise exposure model in which 10 rats were exposed to a 119 dB noise environment for 9 hours daily over a period of 7 consecutive days. Proteomic analysis was performed on urine samples collected from the rats. A comparison of protein expression profiles before and after noise exposure identified 219 differentially expressed proteins, 30 of which are known to be associated with hearing loss. Notably, Gelsolin plays a critical role in regulating the growth and stability of the mechanosensory hair bundles in mammalian cochlear outer hair cells. Deficiency of Lysosome-associated membrane glycoprotein 1 has been reported to cause vacuolization and structural alterations in lysosomal membrane proteins in cochlear marginal cells, leading to hearing loss in mice. Similarly, SLIT and NTRK-like family member 6 deficiency is linked to delayed synaptogenesis and auditory dysfunction in mice. These findings indicate that high-decibel noise exposure induces significant changes in urinary protein expression, many of which are associated with auditory damage as previously reported.

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Yang, M., Zhao, C., Gao, Y.. 2024-12-09. Changes in urinary proteome of rats before and after noise exposure. https://doi.org/10.1101/2024.12.09.627512

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