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bioRxiv · 10.1101/2024.12.04.626829

Adult visual deprivation engages associative, presynaptic plasticity of thalamic input to cortex

Murase, S.·Severin, D.·Dye, L.·Mesik, L.·Moreno, C.·kirkwood, a.·Quinlan, E. M.
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Abstract

Age constrains plasticity at inputs from first order thalamic nuclei to the cortex, endowing stability to ascending, feed-forward projections. However, here we show that prolonged visual deprivation can induce robust and reversible plasticity at thalamocortical synapses in layer 4 pyramidal neurons in the adult mouse primary visual cortex. The plasticity engaged by prolonged visual deprivation is non-homeostatic and mediated by changes in presynaptic function.

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Murase, S., Severin, D., Dye, L., Mesik, L., Moreno, C., kirkwood, a., Quinlan, E. M.. 2024-12-06. Adult visual deprivation engages associative, presynaptic plasticity of thalamic input to cortex. https://doi.org/10.1101/2024.12.04.626829

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