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bioRxiv · 10.1101/2024.12.02.626416

Perception of Temperature Even in the Absence of Actual Change is Sufficient to Drive Transgenerational Epigenetic Inheritance

Abstract

Can processes occurring in one individuals nervous system influence the physiology of the descendants? Here, we explored the hypothesis that parents sensation or perception of environmental cues can influence their offspring, extending across many subsequent generations. We show that in Caenorhabditis elegans, temperature perception by the AFD thermosensory neurons initiates a signaling cascade that, directly or indirectly, induces transgenerational changes in RNAi factors, small RNAs, and their target genes. Moreover, we identify secreted factors that enable this neuron-to-germline communication and trace the path of the epigenetic signal. We further model the process mathematically, and the model yields new predictions that we validate experimentally: blocking sensory input dampens RNAi inheritance initiated by exogenous double-stranded RNA (dsRNA). Together, our results demonstrate that sensory perception is sufficient to influence small RNA-mediated heritable gene expression memory.

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BibTeXRIS

Teichman, G., Sela, M., Ewe, C. K., Rieger, I., Anava, S., Mor, Y., Szanto, P., Meyer, D. H., Doron, H., Shachar, O., Pechuk, V., Gingold, H., Oren-Suissa, M., McGee, M., Shapira, M., Schumacher, B., Rechavi, O.. 2024-12-05. Perception of Temperature Even in the Absence of Actual Change is Sufficient to Drive Transgenerational Epigenetic Inheritance. https://doi.org/10.1101/2024.12.02.626416

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