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bioRxiv · 10.1101/2024.11.29.626128

Wideband Tuning and Deep-Tissue Spectral Detection of Indium Phosphide Nano-Laser Particles

Cho, S.·Moon, W.·Martino, N.·Yun, S.-H.
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Abstract

Laser particles (LPs) emitting narrowband spectra across wide spectral ranges are highly promising for high-multiplex optical barcoding. Here, we present LPs based on indium phosphide (InP) nanodisks, operating in the near-infrared wavelength range of 740-970 nm. Utilizing low-order whispering gallery resonance modes in size-tuned nanodisks, we achieved an ultrawide color palette with 27% bandwidth utilization and nanometer-scale linewidth. The minimum laser size was 430 nm in air and 560 nm within the cytoplasm, operating at mode order 4 or 5. We further demonstrated spectral detection of laser peaks with high signal-to-background ratios in highly-scattering media, including 1-cm-thick chicken breast tissue and blood vessels in live mice.

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Cho, S., Moon, W., Martino, N., Yun, S.-H.. 2024-12-03. Wideband Tuning and Deep-Tissue Spectral Detection of Indium Phosphide Nano-Laser Particles. https://doi.org/10.1101/2024.11.29.626128

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