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bioRxiv · 10.1101/2024.11.29.625631

Lower-limb express visuomotor responses are spared in Parkinson's Disease during step initiation from a stable position

Abstract

While motor impairments have been extensively studied in Parkinsons Disease, rapid visuomotor transformations for flexible interaction with the environment have received surprisingly little attention. In recent years, such rapid visuomotor transformations have been studied in the form of express visuomotor responses (EVRs), which are goal-directed bursts of muscle activity that are thought to originate from superior colliculus, reaching the periphery via the tecto-reticulospinal pathway. Here, we examined EVRs in the lower limbs during goal-directed step initiation in 20 people with Parkisons Disease (PwPD) and 20 age-matched healthy control participants (HC). As lower-limb EVRs in the young have been shown to interact with postural control - which is often affected in PwPD - we manipulated the postural demands by varying initial stance width and target location. In the low postural demand condition, EVRs were robustly present in both the PwPD (17/20) and HC (16/20) group. However, when postural demands were high, EVRs were largely absent in both groups and, instead, strong anticipatory postural adjustments (APAs) were required prior to foot off. EVR magnitudes were, on average, stronger in PwPD compared to HC, but they decreased with increasing disease severity, suggesting that the EVR network may become compromised or down-regulated in later stages of the disease. While APA magnitudes were smaller in PwPD compared to HC, subsequent stepping performance (step reaction time, duration, size, velocity) was remarkably similar between the two groups. We suggest that the EVR network may be upregulated in the early stages of Parkinsons disease in order to compensate for some of the emerging motor deficits experienced in daily life.

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BibTeXRIS

Billen, L. S., Nonnekes, J., Corneil, B. D., Weerdesteyn, V.. 2024-11-30. Lower-limb express visuomotor responses are spared in Parkinson's Disease during step initiation from a stable position. https://doi.org/10.1101/2024.11.29.625631

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