Functional Dichotomy of Orbitofrontal Cortex and Anterior Cingulate Cortex Subregions in Decision-Making and Brain-Body Regulation

Papageorgiou, G. K.; Gibson, D. J.; Amemori, K.-i.; Schwerdt, H. N.; Naim, M.; Wang, M. C.; Yoshida, T.; Sharma, J.; Upadhyay, U.; Yang, G. R.; Graybiel, A. M.

doi:10.1101/2024.11.26.625512

bioRxiv · 10.1101/2024.11.26.625512

Functional Dichotomy of Orbitofrontal Cortex and Anterior Cingulate Cortex Subregions in Decision-Making and Brain-Body Regulation

Papageorgiou, G. K.·Gibson, D. J.·Amemori, K.-i.·Schwerdt, H. N.·Naim, M.·Wang, M. C.·Yoshida, T.·Sharma, J.·Upadhyay, U.·Yang, G. R.·Graybiel, A. M.

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Abstract

Mood disorders are associated with complex disruptions in brain networks, including those associated with the orbitofrontal cortex (OFC) and pregenual anterior cingulate cortex (pACC). The functional contribution of the caudal OFC (cOFC) has remained largely unexplored. We investigated the functions of the cOFC and pACC in macaques performing an approach-avoidance task by the combination of multimodal recordings and electrical microstimulation (EMS) of the cOFC. We assessed neural, autonomic and behavioral responses. We found the cOFC to be sensitive to both positive and negative stimuli, whereas the pACC was singificantly more active during aversive outcomes. EMS of the cOFC increased avoidance behavior, suggesting a causal role for the OFC subdivision in cost-benefit decision-making. Physiological measurements were positively correlated with behavioral patterns, emphasizing body-brain synchronization during emotionally significant decision-making. We suggest that the cOFC contributes to inducing pessimistic states, thereby making its dysfunction a potential contributor to the etiology of mood disorders.

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Papageorgiou, G. K., Gibson, D. J., Amemori, K.-i., Schwerdt, H. N., Naim, M., Wang, M. C., Yoshida, T., Sharma, J., Upadhyay, U., Yang, G. R., Graybiel, A. M.. 2024-11-26. Functional Dichotomy of Orbitofrontal Cortex and Anterior Cingulate Cortex Subregions in Decision-Making and Brain-Body Regulation. https://doi.org/10.1101/2024.11.26.625512

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