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bioRxiv · 10.1101/2024.11.10.622713

A simple method for computationally unstructuring proteins: some findings

Powell, A.
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Abstract

A methodology for computationally unstructuring proteins is described and the results of its application to a variety of proteins analyzed and discussed. Some proteins prove more susceptible than others, and fold topology plays a part in this. Alpha helical structure is found to be generally somewhat robust, and, perhaps unsurprisingly, unstructuring often begins at exposed chain termini. Phosphofructokinase-1 and phosphofructokinase-2, which have similar sizes but different fold topologies, are found to differ markedly in their unstructuring behaviour.

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Powell, A.. 2024-11-12. A simple method for computationally unstructuring proteins: some findings. https://doi.org/10.1101/2024.11.10.622713

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