The development of aperiodic neural activity in the human brain

Cross, Z. R.; Gray, S. M.; Dede, A. J. O.; Rivera, Y. M.; Yin, Q.; Vahidi, P.; Rau, E. M. B.; Cyr, C.; Holubecki, A. M.; Asano, E.; Lin, J. J.; McManus, O. K.; Sattar, S.; Saez, I.; Girgis, F.; King-Stephens, D.; Weber, P. B.; Laxer, K. D.; Schuele, S. U.; Rosenow, J. M.; Wu, J. Y.; Kam, S. K.; Raskin, J. S.; Chang, E. F.; Shaikhouni, A.; Brunner, P.; Roland, J. L.; Braga, R. M.; Knight, R. T.; Ofen, N.; Johnson, E. L.

doi:10.1101/2024.11.08.622714

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bioRxiv · 10.1101/2024.11.08.622714

The development of aperiodic neural activity in the human brain

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Abstract

The neurophysiological mechanisms supporting brain maturation are fundamental to attention and memory capacity across the lifespan. Human brain regions develop at different rates, with many regions developing into the third and fourth decades of life. Here, in this preregistered study (https://osf.io/gsru7), we analyzed intracranial EEG (iEEG) recordings from widespread brain regions in a large developmental cohort. Using task-based (i.e., attention to-be-remembered visual stimuli) and task-free (resting-state) data from 101 children and adults (5.93 - 54.00 years, 63 males; n electrodes = 5691), we mapped aperiodic (1/[f]-like) activity, a proxy of neural noise, with steeper slopes indexing less noise and flatter slopes indexing more noise. We reveal that aperiodic slopes flatten with age into young adulthood in both association and sensorimotor cortices, challenging models of early sensorimotor development based on brain structure. In prefrontal cortex (PFC), attentional state modulated age effects, revealing steeper task-based than task-free slopes in adults and the opposite in children, consistent with the development of cognitive control. Age-related differences in task-based slopes also explained age-related gains in memory performance, linking the development of PFC cognitive control to the development of memory. Last, with additional structural imaging measures, we reveal that age-related differences in gray matter volume are similarly associated with aperiodic slopes in association and sensorimotor cortices. Our findings establish developmental trajectories of aperiodic activity in localized brain regions and illuminate the development of PFC control during adolescence in the development of attention and memory.

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Cross, Z. R., Gray, S. M., Dede, A. J. O., Rivera, Y. M., Yin, Q., Vahidi, P., Rau, E. M. B., Cyr, C., Holubecki, A. M., Asano, E., Lin, J. J., McManus, O. K., Sattar, S., Saez, I., Girgis, F., King-Stephens, D., Weber, P. B., Laxer, K. D., Schuele, S. U., Rosenow, J. M., Wu, J. Y., Kam, S. K., Raskin, J. S., Chang, E. F., Shaikhouni, A., Brunner, P., Roland, J. L., Braga, R. M., Knight, R. T., Ofen, N., Johnson, E. L.. 2024-11-09. The development of aperiodic neural activity in the human brain. https://doi.org/10.1101/2024.11.08.622714

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