Differentiating hallucination proneness dimensions through resting state alpha dynamics

Abstract

BackgroundHallucination-like experiences (HLEs) are untriggered sensory perceptions linked to externalizing bias - the misattribution of self-generated sensory experiences to an external source. The vulnerability to HLEs, i.e., hallucination proneness (HP), is typically assessed by the Launay-Slade Hallucination Scale (LSHS). A recent LSHS factor analysis revealed four distinct HP dimensions: Multisensory HLEs, Auditory daydreaming, Vivid thoughts and inner speech, and Personified HLEs. The current study assesses whether these HP dimensions map onto distinct patterns of resting state brain dynamics in the alpha frequency band due to its modulatory role in attention and perception. MethodsWe used a Hidden semi-Markov Model to segment continuous RS alpha activity into nine recurrent brain states and extracted the total number of transitions (TT) and the number of visits per state (SV). We assessed how the HP dimensions relate to these metrics, calculated across the entire 3-minute recording and within shorter sliding windows to capture finer temporal changes. ResultsAll HP dimensions and increased RS time correlated with increased TT. Increased Personified HLEs scores linked to different time-dependent changes of SV in two states (SV to state 5 decreased over time, while visits to state 9 increased), highlighting distinct alpha dynamics in high- and low-hallucination prone individuals. ConclusionsIncreased TT could indicate frequent attentional switches between internal and external states. Different SV patterns related to higher Personified HLEs scores suggest unstable source monitoring, potentially inducing an externalizing bias. These findings provide novel predictors of HP dimensions, revealing distinct neural profiles associated with different vulnerability profiles.