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bioRxiv · 10.1101/2024.10.31.621330

Epigenetic silencing and host genome evolution determine fate of viral insertions in Acanthamoeba

Abstract

Acanthamoeba is a cosmopolitan freshwater amoebae known for its association with Nucleocytoplasmic Large DNA Viruses (NCLDVs). Previous studies have shown that Acanthamoeba spp. undergo lateral gene transfer (LGT) with NCLDVs. Here we have leveraged chromosome-scale assemblies of two strains of Acanthamoeba castellanii, Neff and C3, to investigate the occurrence and genomic context of viral LGT in Acanthamoeba. We show that the viral footprints in the C3 and Neff genomes are largely non-overlapping and that viral genes in Neff are found disproportionately in large sub-telomeric insertions. Multiple partial copies of these insertions are found throughout the Neff genome, but they are not expressed and do not encode functions for their own mobility. Viral regions are hyper-methylated and highly condensed, suggesting that the expression of recently acquired viral DNA is suppressed in heterochromatic regions. We propose a three-step model for the origin and fate of viral sequences in Acanthamoeba: (i) integration of DNA from giant viruses, (ii) epigenetic suppression of the viral DNAs, which allows them to persist in the genome, and (iii) deterioration of viral genomes by point mutation and intra- and inter-chromosomal recombination. Viral integrations in Acanthamoeba spp. are transient and may not have long-lasting effects on the fitness of the host amoeba. Our work strengthens a growing body of work showing widespread but transient integration of viral DNA in protists and extends the relevance of epigenetic silencing mechanisms to the evolution of Amoebozoa. We highlight the importance of host genome dynamics for understanding the evolution of endogenized viral elements.

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BibTeXRIS

Blais, C., Colp, M. J., Sarre, L. A., de Mendoza, A., Archibald, J. M.. 2024-11-03. Epigenetic silencing and host genome evolution determine fate of viral insertions in Acanthamoeba. https://doi.org/10.1101/2024.10.31.621330

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