Pupil dilation offers a time-window on prediction error

Abstract

Task-evoked pupil dilation has been linked to many cognitive variables, perhaps most notably unexpected events. Zenon (2019) proposed a unifying framework stating that pupil dilation related to cognition should be considered from an information-theory perspective. In the current study, we investigated whether the pupils response to decision outcome in the context of associative learning reflects a prediction error signal defined operationally as an interaction between stimulus-pair frequency and accuracy, while also exploring the time course of this prediction error signal. Thereafter, we tested whether these prediction error signals correlated with information gain, defined formally as the KL divergence between posterior and prior belief distributions of the ideal observer. We reasoned that information gain should be proportional to the (precision-weighted) prediction error signals potentially arising from neuromodulatory arousal networks. To do so, we adapted a simple model of trial-by-trial learning of stimulus probabilities based on information theory from previous literature. We analyzed two data sets in which participants performed perceptual decision-making tasks that required associative learning while pupil dilation was recorded. Our findings consistently showed that a significant proportion of variability in the post-feedback pupil response during decision-making can be explained by a formal quantification of information gain shortly after feedback presentation in both task contexts. In the later time window, the relationship between information-theoretic variables and the post-feedback pupil response differed per task. For the first time, we present evidence that whether the post-feedback pupil dilates or constricts along with information gain was context dependent. This study offers empirical evidence showcasing how the pupils response can offer valuable insights into the process of model updating during learning, highlighting the promising utility of this readily accessible physiological indicator for investigating internal belief states.