Complex Properties of Training Stimuli Affect Brain Alignment in a Deep Network Model of Mouse Visual Cortex

Abstract

Deep convolutional neural networks are important models of the visual cortex that ac-count relatively well for brain activity and are able to perform ethologically relevant functions. However, it is unknown which combination of factors, such as network ar-chitecture, training objectives, and data best align this family of models with the brain. Here we investigate the statistics of training data. We hypothesized that stimuli that are naturalistic for mice would lead to higher similarity between deep network models and activity in mouse visual cortex. We used a video-game engine to create training datasets in which we varied the naturalism of the environment, the movement statis-tics, and the optics of the modelled eye. The naturalistic environment substantially and consistently led to greater brain similarity, while the other factors had more subtle and area-specific effects. We then hypothesized that differences in brain similarity between the two environments arose due to differences in spatial frequency spectra, distribu-tions of color and orientation, and/or temporal autocorrelations. To test this, we created abstract environments, composed of cubes and spheres, that resembled the naturalis-tic and non-naturalistic environments in these respects. Contrary to our expectations, these factors accounted poorly for differences in brain similarity due to the naturalis-tic and non-naturalistic environments. This suggests that the higher brain similarities we observed after training with the naturalistic environment were due to more complex factors.