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bioRxiv · 10.1101/2024.10.23.619790

The computational bottleneck of basal ganglia output (and what to do about it)

Abstract

What the basal ganglia do is an oft-asked question; answers range from the selection of actions to the specification of movement to the estimation of time. Here I argue that how the basal ganglia do what they do is a less-asked but equally important question. I show that the output regions of the basal ganglia create a stringent computational bottleneck, both structurally, because they have far fewer neurons than do their target regions, and dynamically, because of their tonic, inhibitory output. My proposed solution to this bottleneck is that the activity of an output neuron is setting the weight of a basis function, a function defined by that neurons synaptic contacts. I illustrate how this may work in practice, allowing basal ganglia output to shift cortical dynamics and control eye movements via the superior colliculus. This solution can account for troubling issues in our understanding of the basal ganglia: why we see output neurons increasing their activity during behaviour, rather than only decreasing as predicted by theories based on disinhibition, and why the output of the basal ganglia seems to have so many codes squashed into such a tiny region of the brain. Significance statementThe basal ganglia are implicated in an extraordinary range of functions, from action selection to timing, and dysfunctions, from Parkinsons disease to obsessive compulsive disorder. Yet however the basal ganglia cause these functions and dysfunctions they must do so through a group of neurons that are dwarfed in number by both their inputs and their output targets. Here I lay out this bottleneck problem for basal ganglia computation, and propose a solution to how their outputs can control their many targets. That solution rethinks the output connections of the basal ganglia as a set of basis functions. In doing so, it provides explanations for previously troubling data on basal ganglia output, and strong predictions for how that output controls its targets.

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BibTeXRIS

Humphries, M. D.. 2024-10-24. The computational bottleneck of basal ganglia output (and what to do about it). https://doi.org/10.1101/2024.10.23.619790

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