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bioRxiv · 10.1101/2024.10.16.618635

Pre-existing intratumoral stem-like CD8+ T-cells drive radiotherapy-induced tumor control

Koksal, H.·Herbst, M.·Pereira, P.·Nater, M.·Regli, N.·Boudjeniba, C.·Erdem Borgoni, N.·Cecconi, V.·van den Broek, M.
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Abstract

CD8+ T-cells are essential for spontaneous and therapy-induced restriction of tumor progression. Upon radiotherapy, these pre-existing CD8+ T-cells expand rapidly after their initial decline and are essential and sufficient for early tumor control. Stem-like CD8+ T-cells proliferate and differentiate into effector CD8+ T-cells in response to radiotherapy and are thus key determinants of therapy efficacy. Our findings highlight the critical role of intratumoral stem-like CD8+ T-cells in driving radiotherapy-induced anti-tumor immunity. Our study provides deeper insights into the dynamic behavior of CD8+ T-cells and their critical involvement in tumor control following radiotherapy.

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Koksal, H., Herbst, M., Pereira, P., Nater, M., Regli, N., Boudjeniba, C., Erdem Borgoni, N., Cecconi, V., van den Broek, M.. 2024-10-18. Pre-existing intratumoral stem-like CD8+ T-cells drive radiotherapy-induced tumor control. https://doi.org/10.1101/2024.10.16.618635

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