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bioRxiv · 10.1101/2024.10.13.618022

A biophysically-detailed model of inter-areal interactions in cortical sensory processing

Abstract

Mechanisms of top-down modulation in sensory perception and their relation to underlying connectivity are not completely understood. We present here a biophysically-detailed computational model of two interconnected cortical areas, representing the first steps in a cortical processing hierarchy, as a tool for potential discovery. The model integrates a large body of data from rodent primary somatosensory cortex and reproduces biological features across multiple scales: from a handful of ion channels defining a diversity of electrical types in hundreds of thousands of morphologically detailed neurons, to local and long-range networks mediated by hundreds of millions of synapses. Notably, long-range connectivity in the model incorporates target lamination patterns associated with feed-forward and feedback pathways. We use the model to study the impact of inter-areal interactions on sensory processing. First, we exhibit a cortico-cortical loop between the two model areas (X and Y), wherein sensory input to area X produces a response with two components in time, the first driven by the stimulus and the second by feedback from area Y. We perform a structural and functional characterization of this loop, finding a differential impact of layer-specific pathways in the feed-forward and feedback directions. Second, we explore stimulus discrimination by presenting four different spatially-segregate stimulus patterns. We observe well-defined temporal sequences of functional cell assembly activation, with stimulus specificity in early but not late assemblies in area X, i.e., in the stimulus-driven component of the response but not in the feedback-driven component. We also find the earliest assembly in area Y to be specific to pairs of patterns, consistent with the topography of connections. Finally, we examine the integration of bottom-up and top-down signals. When presenting a second stimulus coincident with the feedback-driven component, we observe an approximate linear superposition of responses. The implied lack of interaction is consistent with the stochastic and hence naive connectivity in the model, but provides a useful foundation for plasticity mechanisms to learn top-down influences. This work represents a first step in the study of inter-areal interactions with biophysically-detailed simulations.

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BibTeXRIS

Bolanos-Puchet, S., Reimann, M. W.. 2024-10-13. A biophysically-detailed model of inter-areal interactions in cortical sensory processing. https://doi.org/10.1101/2024.10.13.618022

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