The Greenland shark (Somniosus microcephalus) genome provides insights into extremelongevity

Sahm, A.; Cherkasov, A.; Liu, H.; Voronov, D.; Siniuk, K.; Schwarz, R.; Ohlenschlaeger, O.; Foerste, S.; Bens, M.; Groth, M.; Goerlich, I.; Paturej, S.; Klages, S.; Braendl, B.; Olsen, J.; Bushnell, P.; Poulsen, A. B.; Ferrando, S.; Garibaldi, F.; Drago, D. L.; Tozzini, E. T.; Mueller, F.-J.; Fischer, M.; Kretzmer, H.; Domenici, P.; Steffensen, J. F.; Cellerino, A.; Hoffmann, S.

doi:10.1101/2024.09.09.611499

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bioRxiv · 10.1101/2024.09.09.611499

The Greenland shark (Somniosus microcephalus) genome provides insights into extremelongevity

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Abstract

The Greenland shark (Somniosus microcephalus) is the longest-lived vertebrate known, with an estimated lifespan of [~] 400 years. Here, we present a chromosome-level assembly of the 6.45 Gb Greenland shark, rendering it one of the largest non-tetrapod genomes sequenced so far. Expansion of the genome is mostly accounted for by a substantial expansion of transposable elements. Using public shark genomes as a comparison, we found that genes specifically duplicated in the Greenland shark form a functionally connected network enriched for DNA repair function. Furthermore, we identified a unique insertion in the conserved C-terminal region of the key tumor suppressor p53. We also provide a public browser to explore its genome.

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Sahm, A., Cherkasov, A., Liu, H., Voronov, D., Siniuk, K., Schwarz, R., Ohlenschlaeger, O., Foerste, S., Bens, M., Groth, M., Goerlich, I., Paturej, S., Klages, S., Braendl, B., Olsen, J., Bushnell, P., Poulsen, A. B., Ferrando, S., Garibaldi, F., Drago, D. L., Tozzini, E. T., Mueller, F.-J., Fischer, M., Kretzmer, H., Domenici, P., Steffensen, J. F., Cellerino, A., Hoffmann, S.. 2024-09-10. The Greenland shark (Somniosus microcephalus) genome provides insights into extremelongevity. https://doi.org/10.1101/2024.09.09.611499

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