Cross-species brain-wide mapping reveals a conserved and coordinated network engaged by NAc DBS

Feng, A.; Barbosa, D. A. N.; Casey, A. B.; Rijsketic, D. R.; Salgado, J. S.; Huang, H.; Malenka, R. C.; Dora, H.; Miller, K. J.; Halpern, C.; Heifets, B. D.

doi:10.1101/2024.09.08.611940

bioRxiv · 10.1101/2024.09.08.611940

Cross-species brain-wide mapping reveals a conserved and coordinated network engaged by NAc DBS

Feng, A.·Barbosa, D. A. N.·Casey, A. B.·Rijsketic, D. R.·Salgado, J. S.·Huang, H.·Malenka, R. C.·Dora, H.·Miller, K. J.·Halpern, C.·Heifets, B. D.

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Abstract

SummaryNucleus accumbens (NAc) deep brain stimulation (DBS) has been increasingly explored as a treatment modality for refractory neuropsychiatric disorders. Uncovering the accumbens network that is engaged by DBS is a critical step forward in understanding how modulating this important node impacts the broader mesocorticolimbic circuit. Using whole-brain clearing and unbiased, brain-wide neural activity mapping, we found that NAc DBS increases neural activity in a coordinated mesocorticolimbic network in mice. Simultaneous intracranial electrophysiology recordings from the human NAc and brief stimulation epochs of homologous mesocorticolimbic nodes revealed similar connectivity. Altogether, these results identify specific connectivity conserved across species within the mesocorticolimbic circuit that may underlie mechanisms of NAc DBS.

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Feng, A., Barbosa, D. A. N., Casey, A. B., Rijsketic, D. R., Salgado, J. S., Huang, H., Malenka, R. C., Dora, H., Miller, K. J., Halpern, C., Heifets, B. D.. 2024-09-09. Cross-species brain-wide mapping reveals a conserved and coordinated network engaged by NAc DBS. https://doi.org/10.1101/2024.09.08.611940

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