Recovery of Verbal Working Memory Depends on Left Hemisphere White Matter Tracts

Martin, R. C.; Ding, J.; Alwani, A. I.; Fung, S. H.; Schnur, T. T.

doi:10.1101/2024.08.16.608246

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bioRxiv · 10.1101/2024.08.16.608246

Recovery of Verbal Working Memory Depends on Left Hemisphere White Matter Tracts

Martin, R. C.·Ding, J.·Alwani, A. I.·Fung, S. H.·Schnur, T. T.

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Abstract

Researchers propose that the recovery of language function following stroke depends on the recruitment of perilesional regions in the left hemisphere and/or homologous regions in the right hemisphere (Kiran, 2012). Many investigations of recovery focus on changes in gray matter regions (e.g., Turkeltaub et al., 2011), whereas relatively few examine white matter tracts (e.g., Schlaug et al., 2009) and none address the role of these tracts in the recovery of verbal working memory (WM). The present study addressed these gaps, examining the role of left vs. right hemisphere tracts in the longitudinal recovery of phonological and semantic WM. For 24 individuals with left hemisphere stroke, we assessed WM performance within one week of stroke (acute timepoint) and at more than six months after stroke (chronic timepoint). To address whether recovery depends on the recruitment of left or right hemisphere tracts, we assessed whether changes in WM were related to the integrity of five white matter tracts in the left hemisphere which had been implicated previously in verbal WM and their right hemisphere analogues. Behavioral results showed significant improvement in semantic but not phonological WM from the acute to chronic timepoints. Improvements in semantic WM significantly correlated with tract integrity as measured by functional anisotropy in the left direct segment of the arcuate fasciculus, inferior fronto-occipital fasciculus and inferior longitudinal fasciculus. The results confirm the role of white matter tracts in language recovery and support the involvement of the left rather than right hemisphere in the recovery of semantic WM.

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Martin, R. C., Ding, J., Alwani, A. I., Fung, S. H., Schnur, T. T.. 2024-08-17. Recovery of Verbal Working Memory Depends on Left Hemisphere White Matter Tracts. https://doi.org/10.1101/2024.08.16.608246

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