Enhanced replication of contemporary human highly pathogenic avian influenza H5N1 virus isolate in human lung organoids compared to bovine isolate

Flagg, M.; Williamson, B. N.; Ortiz-Morales, J. A.; Lutterman, T.; de Wit, E.

doi:10.1101/2024.08.02.606417

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bioRxiv · 10.1101/2024.08.02.606417

Enhanced replication of contemporary human highly pathogenic avian influenza H5N1 virus isolate in human lung organoids compared to bovine isolate

Flagg, M.·Williamson, B. N.·Ortiz-Morales, J. A.·Lutterman, T.·de Wit, E.

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Abstract

We compared virus replication and host responses in human alveolar epithelium infected with highly pathogenic avian influenza (HPAI) H5N1 viruses. A/Vietnam/1203/2004 replicated most efficiently, followed by A/Texas/37/2024, then A/bovine/Ohio/B24OSU-342/2024. Induction of interferon-stimulated genes was lower with A/Texas/37/2024 and A/bovine/Ohio/B24OSU-342/2024, which may indicate a reduced disease severity of these viruses.

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Flagg, M., Williamson, B. N., Ortiz-Morales, J. A., Lutterman, T., de Wit, E.. 2024-08-03. Enhanced replication of contemporary human highly pathogenic avian influenza H5N1 virus isolate in human lung organoids compared to bovine isolate. https://doi.org/10.1101/2024.08.02.606417

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