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bioRxiv · 10.1101/2024.07.19.604219

Structural diversity of mitochondria in the neuromuscular system across development

Abstract

As an animal matures, its neural circuit undergoes alterations, yet the developmental changes in intracellular organelles to facilitate these changes is less understood. Using 3D electron microscopy and deep learning, we developed semi-automated methods for reconstructing mitochondria in C. elegans and collected mitochondria reconstructions from normal reproductive stages and dauer, enabling comparative study on mitochondria structure within the neuromuscular system. We found that various mitochondria structural properties in neurons correlate with synaptic connections and these properties are preserved across development in different neural circuits. To test the necessity of these universal mitochondria properties, we examined the behavior in drp-1 mutants with impaired mitochondria fission and discovered that it caused behavioral deficits. Moreover, we observed that dauer neurons display distinctive mitochondrial features, and mitochondria in dauer muscles exhibit unique reticulum-like structure. We propose that this specialized mitochondria structure may serve as an adaptive mechanism to support stage-specific behavioral and physiological needs.

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BibTeXRIS

Bae, J. A., Choi, M.-k., Ahn, S., Ko, G., Choe, D. T., Yim, H., Nguyen, K. C. Q., Hall, D. H., Kim, J. S., Lee, J.. 2024-07-23. Structural diversity of mitochondria in the neuromuscular system across development. https://doi.org/10.1101/2024.07.19.604219

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