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bioRxiv · 10.1101/2024.07.01.601566

Identification of mCMQ069, a novel antimalarial with potential for a single-dose cure and/or 28-day chemoprevention

Gupta, A. K.·Pedroarena, J.·Nazarian, A.·Antonova-Koch, J.·Weiss, F.·Kumpornsin, K.·Chi, V.·Woods, A. K.·Lee, K.-J.·Joseph, S. B.·Li, S.·Brittain, J.·Hostos, E. D.·Duffy, J.·Cooper, A.·Schultz, P. G.·McNamara, C. W.·Chatterjee, A. K.
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Abstract

In efforts towards eliminating malaria, a discovery program was initiated to identify a novel antimalarial using KAF156 as a starting point. Following the most recent TCP/TPP guidelines, we have identified mCMQ069 with a predicted single oral dose for treatment ([~]40-106 mg) and one-month chemoprevention ([~]96-216 mg). We have improved unbound MPC and predicted human clearance by 18-fold and 10-fold respectively when compared to KAF156.

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Gupta, A. K., Pedroarena, J., Nazarian, A., Antonova-Koch, J., Weiss, F., Kumpornsin, K., Chi, V., Woods, A. K., Lee, K.-J., Joseph, S. B., Li, S., Brittain, J., Hostos, E. D., Duffy, J., Cooper, A., Schultz, P. G., McNamara, C. W., Chatterjee, A. K.. 2024-07-01. Identification of mCMQ069, a novel antimalarial with potential for a single-dose cure and/or 28-day chemoprevention. https://doi.org/10.1101/2024.07.01.601566

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