Increasing the representation of minoritized youth for inclusive and reproducible brain-behavior associations

Ramduny, J.; Uddin, L. Q.; Vanderwal, T.; Feczko, E.; Fair, D. A.; Kelly, C.; Baskin-Sommers, A.

doi:10.1101/2024.06.22.600221

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bioRxiv · 10.1101/2024.06.22.600221

Increasing the representation of minoritized youth for inclusive and reproducible brain-behavior associations

Ramduny, J.·Uddin, L. Q.·Vanderwal, T.·Feczko, E.·Fair, D. A.·Kelly, C.·Baskin-Sommers, A.

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Abstract

Population neuroscience datasets allow researchers to estimate reliable effect sizes for brain-behavior associations because of their large sample sizes. However, these datasets undergo strict quality control to mitigate sources of noise, such as head motion. This practice often excludes a disproportionate number of minoritized individuals. We employ motion-ordering and motion-ordering+resampling (bagging) to test if these methods preserve functional MRI (fMRI) data in the Adolescent Brain Cognitive Development Study (N=5,733). Black and Hispanic youth exhibited excess head motion relative to data collected from White youth, and were discarded disproportionately when using conventional approaches. Both methods retained more than 99% of Black and Hispanic youth. They produced reproducible brain-behavior associations across low-/high-motion racial/ethnic groups based on motion-limited fMRI data. The motion-ordering and bagging methods are two feasible approaches that can enhance sample representation for testing brain-behavior associations and fulfill the promise of consortia datasets to produce generalizable effect sizes across diverse populations.

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Ramduny, J., Uddin, L. Q., Vanderwal, T., Feczko, E., Fair, D. A., Kelly, C., Baskin-Sommers, A.. 2024-06-28. Increasing the representation of minoritized youth for inclusive and reproducible brain-behavior associations. https://doi.org/10.1101/2024.06.22.600221

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