Poly-unsaturated Fatty Acids from Thamnidium elegans and Mortierella alpina Suppress Prostate Cancer Cells Proliferation and Migration

Kalampounias, G.; Dritsas, P.; Karayannis, D.; Androutsopoulou, T.; Gardeli, C.; Papanikolaou, S.; Aggelis, G.; Katsoris, P.

doi:10.1101/2024.06.05.597505

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bioRxiv · 10.1101/2024.06.05.597505

Poly-unsaturated Fatty Acids from Thamnidium elegans and Mortierella alpina Suppress Prostate Cancer Cells Proliferation and Migration

Kalampounias, G.·Dritsas, P.·Karayannis, D.·Androutsopoulou, T.·Gardeli, C.·Papanikolaou, S.·Aggelis, G.·Katsoris, P.

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Abstract

Thamnidium elegans and Mortierella alpina are two oleaginous fungi that belong to Mucoromycota that synthesize polyunsaturated fatty acids which are credited with multiple health benefits and possible anticancer properties. These fungi were cultivated on culture media with glucose or glycerol as a carbon source. After extracting the lipids, we transformed them into fatty acid lithium salts (FALS), which are water-soluble and absorbable mammalian cells, including DU-145 and PC-3 cancer cells. The two cell lines, both long-established prostate cancer models, were treated with FALS and indicated increased susceptibility to the lipid derivatives. The viability and proliferation rates were significantly reduced, as well as their migratory capabilities, which were significantly impaired compared to olive-oil-derived FALS, which were used as a control substance. We conclude that the FALS derivatives of microbial lipids from these organisms exhibit anticancer effects by suppressing the proliferation and migration of human prostate cancer cell lines.

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Kalampounias, G., Dritsas, P., Karayannis, D., Androutsopoulou, T., Gardeli, C., Papanikolaou, S., Aggelis, G., Katsoris, P.. 2024-06-06. Poly-unsaturated Fatty Acids from Thamnidium elegans and Mortierella alpina Suppress Prostate Cancer Cells Proliferation and Migration. https://doi.org/10.1101/2024.06.05.597505

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