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bioRxiv · 10.1101/2024.06.03.597265

Mild traumatic brain injury is associated with increased thalamic subregion volume in the subacute period following injury

Baird, M. E.·Beare, R. E.·Seal, M. L.·Yang, J. Y.-M.·Anderson, J. F.
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Abstract

Structural vulnerability of the thalamus remains under investigated in mild traumatic brain injury (mTBI), and few studies have addressed its constituent nuclei using robust segmentation methods. This study aimed to investigate thalamic subnuclei volume in the subacute period following mTBI. Trauma control (TC) and mTBI patients aged 18 - 60 years old completed an MRI neuroimaging protocol including both high resolution structural (T1w) and diffusion weighted sequences at 6 - 11 weeks following injury (mean: 57 days; sd 11). Each thalamus was segmented into its constituent subnuclei, which were grouped into eight lateralised subregions. Volumes of the subregions were calculated. Neurite Orientation Dispersion and Density (NODDI) maps with parameters optimised for grey matter were computed for the same subregions. Group differences in subregion volumes and NODDI parameters were investigated using Bayesian linear modelling, with age, sex, and intracranial volume included as covariates. Comparisons of mTBI (n = 39) and TC (n = 28) groups revealed evidence of relatively increased grey matter volume in the mTBI group for the bilateral medial and right intralaminar subregions (BF10 > 3). Of the subregions which showed volume differences, there was no evidence for differences in NODDI metrics between groups. This study demonstrates that in the subacute period following mTBI, there is evidence of increased volume in specific thalamic subregions. Putative mechanisms underpinning the increased volume observed here are disordered remyelination, or myelin debris yet to be cleared. Significance statementDespite the prevalence of continued cognitive, somatic, and vestibular symptoms in the subacute period (6 - 12 weeks) following an mTBI, a clear neuropathophysiological profile is yet to be determined. One key vulnerable structure in mTBI could be the thalamus, a subcortical grey matter structure which comprises numerous subregions. The present study investigated whether changes in thalamic subregion volume are evident in the subacute period. For the first time, we show that at approximately 8 weeks following injury, mTBI is associated with increased volume in specific thalamus subregions. This provides an important avenue for continued investigation into the clinical significance of these findings.

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Baird, M. E., Beare, R. E., Seal, M. L., Yang, J. Y.-M., Anderson, J. F.. 2024-06-04. Mild traumatic brain injury is associated with increased thalamic subregion volume in the subacute period following injury. https://doi.org/10.1101/2024.06.03.597265

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