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bioRxiv · 10.1101/2024.05.19.594912

A Human iPSC-derived Organoid System to Model Myelin Destruction and Repair

Ramesan, S.·Mason, J.·Swanson, M. E. V.·Mills, S.·Turner, B. J.·Rutar, M.·Gonsalvez, D. G.·Barton, S. K.
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Abstract

We engineered a novel human iPSC-derived organoid system enriched with mature, myelinating oligodendrocytes and functionally reactive microglia. This model enables the study of human CNS remyelination following a demyelinating insult, encapsulating: myelin fragmentation, microglial clearance of myelin debris and oligodendrocyte genesis, differentiation, and axon ensheathment. This system provides a powerful and unparalleled capacity to interrogate complex human cell behaviour, relevant to those studying glial biology and neurological disease mechanisms.

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Ramesan, S., Mason, J., Swanson, M. E. V., Mills, S., Turner, B. J., Rutar, M., Gonsalvez, D. G., Barton, S. K.. 2024-05-20. A Human iPSC-derived Organoid System to Model Myelin Destruction and Repair. https://doi.org/10.1101/2024.05.19.594912

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