Stable, chronic in-vivo recordings from a fully wireless subdural-contained 65,536-electrode brain-computer interface device

Jung, T.; Zeng, N.; Fabbri, J. D.; Eichler, G.; Li, Z.; Willeke, K.; Wingel, K. E.; Dubey, A.; Huq, R.; Sharma, M.; Hu, Y.; Ramakrishnan, G.; Tien, K.; Mantovani, P.; Parihar, A.; Yin, H.; Oswalt, D.; Misdorp, A.; Uguz, I.; Shinn, T.; Rodriguez, G. J.; Nealley, C.; Gonzales, I.; Roukes, M.; Knecht, J.; Yoshor, D.; Canoll, P.; Spinazzi, E.; Carloni, L. P.; Pesaran, B.; Patel, S.; Youngerman, B.; Cotton, R. J.; Tolias, A.; Shepard, K. L.

doi:10.1101/2024.05.17.594333

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bioRxiv · 10.1101/2024.05.17.594333

Stable, chronic in-vivo recordings from a fully wireless subdural-contained 65,536-electrode brain-computer interface device

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Abstract

Minimally invasive, high-bandwidth brain-computer-interface (BCI) devices can revolutionize human applications. With orders-of-magnitude improvements in volumetric efficiency over other BCI technologies, we developed a 50-m-thick, mechanically flexible micro-electrocorticography (ECoG) BCI, integrating a 256x256 array of electrodes, signal processing, data telemetry, and wireless powering on a single complementary metal-oxide-semiconductor (CMOS) substrate containing 65,536 recording channels, from which we can simultaneously record a selectable subset of up to 1024 channels at a given time. Fully implanted below the dura, our chip is wirelessly powered, communicating bi-directionally with an external relay station outside the body. We demonstrated chronic, reliable recordings for up to two weeks in pigs and up to two months in behaving non-human primates from somatosensory, motor, and visual cortices, decoding brain signals at high spatiotemporal resolution.

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Jung, T., Zeng, N., Fabbri, J. D., Eichler, G., Li, Z., Willeke, K., Wingel, K. E., Dubey, A., Huq, R., Sharma, M., Hu, Y., Ramakrishnan, G., Tien, K., Mantovani, P., Parihar, A., Yin, H., Oswalt, D., Misdorp, A., Uguz, I., Shinn, T., Rodriguez, G. J., Nealley, C., Gonzales, I., Roukes, M., Knecht, J., Yoshor, D., Canoll, P., Spinazzi, E., Carloni, L. P., Pesaran, B., Patel, S., Youngerman, B., Cotton, R. J., Tolias, A., Shepard, K. L.. 2024-05-17. Stable, chronic in-vivo recordings from a fully wireless subdural-contained 65,536-electrode brain-computer interface device. https://doi.org/10.1101/2024.05.17.594333

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