A systematic review of laboratory investigations into the pathogenesis of avian influenza viruses in wild avifauna of North America

Abstract

The lack of consolidated information regarding wild bird species response to avian influenza virus (AIV) infection is a challenge for conservation managers, researchers, and related sectors such as public health and commercial poultry. Such information could be used to model complex disease dynamics within communities, prioritize species for surveillance and conservation efforts, or identify species more likely to facilitate spillover into domestic animals or humans. Using two independent searches, we reviewed published literature for studies describing wild bird species experimentally infected with avian influenza to assess host species relative susceptibility to AIVs. Additionally, we summarized broad-scale parameters for elements such as shedding duration and minimum infectious dose that can be used in transmission modeling efforts. Our synthesis documented that waterfowl (i.e., Anatidae) comprise the vast majority of published AIV pathobiology studies, whereas gulls and passerines were less represented in research despite evidence that they also are susceptible and contribute to high pathogenicity avian influenza disease dynamics. This study represents the first comprehensive effort to compile available literature regarding the pathobiology of AIVs in all wild birds in over a decade. This database provides an opportunity to critically examine and assess what is known and identify where further insight is needed.