Evolutionary convergence of sensory circuits in the pallium of amniotes

Rueda-Alana, E.; Senovilla-Ganzo, R.; Grillo, M.; Vazquez, E.; Gallego-Flores, T.; Marco-Salas, S.; Ftara, A.; Escobar, L.; Benguria, A.; Quintas-Gorozarri, A.; Dopazo, A.; Rabano, M.; dM Vivanco, M.; Aransay, A. M.; Garrigos, D.; Toval, A.; Ferran, J. L.; Nilsson, M.; Encinas, J. M.; de Pitta, M.; Garcia-Moreno, F.

doi:10.1101/2024.04.30.591819

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bioRxiv · 10.1101/2024.04.30.591819

Evolutionary convergence of sensory circuits in the pallium of amniotes

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Abstract

The amniote pallium contains sensory circuits structurally and functionally equivalent, yet their evolutionary relationship remains unresolved. Our study employs birthdating analysis, single-cell RNA and spatial transcriptomics, and mathematical modeling to compare the development and evolution of known pallial circuits across birds (chick), lizards (gecko) and mammals (mouse). We reveal that neurons within these circuits stations are generated at varying developmental times and brain regions across species, and found an early developmental divergence in the transcriptomic progression of glutamatergic neurons. Together, we show divergent developmental and evolutionary trajectories in the pallial cell types of sauropsids and mammals. Our research highlights significant differences in circuit construction rules among species and pallial regions. Interestingly, despite these developmental distinctions, the sensory circuits in birds and mammals appear functionally similar, which suggest the convergence of high-order sensory processing across amniote lineages.

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Rueda-Alana, E., Senovilla-Ganzo, R., Grillo, M., Vazquez, E., Gallego-Flores, T., Marco-Salas, S., Ftara, A., Escobar, L., Benguria, A., Quintas-Gorozarri, A., Dopazo, A., Rabano, M., dM Vivanco, M., Aransay, A. M., Garrigos, D., Toval, A., Ferran, J. L., Nilsson, M., Encinas, J. M., de Pitta, M., Garcia-Moreno, F.. 2024-05-02. Evolutionary convergence of sensory circuits in the pallium of amniotes. https://doi.org/10.1101/2024.04.30.591819

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