Corticospinal and corticoreticulospinal projections benefit motor behaviors in chronic stroke

Taga, M.; Hong, Y. N. G.; Charalambous, C. C.; Raju, S.; Hayes, L.; Lin, J.; Zhang, Y.; Shao, Y.; Houston, M.; Mazzoni, P.; Roh, J.; Schambra, H.

doi:10.1101/2024.04.04.588112

bioRxiv · 10.1101/2024.04.04.588112

Corticospinal and corticoreticulospinal projections benefit motor behaviors in chronic stroke

Taga, M.·Hong, Y. N. G.·Charalambous, C. C.·Raju, S.·Hayes, L.·Lin, J.·Zhang, Y.·Shao, Y.·Houston, M.·Mazzoni, P.·Roh, J.·Schambra, H.

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Abstract

After corticospinal tract (CST) stroke, several motor deficits in the upper extremity (UE) emerge, including diminished muscle strength, motor control, and muscle individuation. Both the ipsilesional CST and contralesional corticoreticulospinal tract (CReST) innervate the paretic UE and may have different innervation patterns for the proximal and distal UE segments. These patterns may underpin distinct pathway relationships to separable motor behaviors. In this cross-sectional study of 15 chronic stroke patients and 28 healthy subjects, we examined two key questions: (1) whether segmental motor behaviors differentially relate to ipsilesional CST and contralesional CReST projection strengths, and (2) whether motor behaviors segmentally differ in the paretic UE. We measured strength, motor control, and muscle individuation in a proximal (biceps, BIC) and distal muscle (first dorsal interosseous, FDI) of the paretic UE. We measured the projection strengths of the ipsilesional CST and contralesional CReST to these muscles using transcranial magnetic stimulation (TMS). Stroke subjects had abnormal motor control and muscle individuation despite strength comparable to healthy subjects. In stroke subjects, stronger ipsilesional CST projections were linked to superior motor control in both UE segments, whereas stronger contralesional CReST projections were linked to superior muscle strength and individuation in both UE segments. Notably, both pathways also shared associations with behaviors in the proximal segment. Motor control deficits were segmentally comparable, but muscle individuation was worse for distal motor performance. These results suggest that each pathway has specialized contributions to chronic motor behaviors but also work together, with varying levels of success in supporting chronic deficits. Key points summaryO_LIIndividuals with chronic stroke typically have deficits in strength, motor control, and muscle individuation in their paretic upper extremity (UE). It remains unclear how these altered behaviors relate to descending motor pathways and whether they differ by proximal and distal UE segment. C_LIO_LIIn this study, we used transcranial magnetic stimulation (TMS) to examine projection strengths of the ipsilesional corticospinal tract (CST) and contralesional corticoreticulospinal tract (CReST) with respect to quantitated motor behaviors in chronic stroke. C_LIO_LIWe found that stronger ipsilesional CST projections were associated with better motor control in both UE segments, whereas stronger contralesional CReST projections were associated with better strength and individuation in both UE segments. In addition, projections of both pathways shared associations with motor behaviors in the proximal UE segment. C_LIO_LIWe also found that deficits in strength and motor control were comparable across UE segments, but muscle individuation was worse with controlled movement in the distal UE segment. C_LIO_LIThese results suggest that the CST and CReST have specialized contributions to chronic motor behaviors and also work together, although with different degrees of efficacy. C_LI

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Taga, M., Hong, Y. N. G., Charalambous, C. C., Raju, S., Hayes, L., Lin, J., Zhang, Y., Shao, Y., Houston, M., Mazzoni, P., Roh, J., Schambra, H.. 2024-04-08. Corticospinal and corticoreticulospinal projections benefit motor behaviors in chronic stroke. https://doi.org/10.1101/2024.04.04.588112

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