Non-invasive and painless mid-infrared modulation increases collagen in human and mouse skin

Wang, Z.; Zhu, J.; Wang, Y.; Chen, S.; Xu, S.; Li, Y.; Hu, T.; Wang, X.; Ji, R.; Li, S. C.; Yang, Y.; Jia, H.; Chen, X.; Fan, X.; Ge, L.; Zhang, J.

doi:10.1101/2024.03.28.587170

bioRxiv · 10.1101/2024.03.28.587170

Non-invasive and painless mid-infrared modulation increases collagen in human and mouse skin

Wang, Z.·Zhu, J.·Wang, Y.·Chen, S.·Xu, S.·Li, Y.·Hu, T.·Wang, X.·Ji, R.·Li, S. C.·Yang, Y.·Jia, H.·Chen, X.·Fan, X.·Ge, L.·Zhang, J.

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Abstract

Stimulating collagen production in skin helps to enhance vitality while decelerating aging- associated processes in skin tissue. However, current approaches to enhancing collagen production are commonly limited by accompanying pain and trauma. Here, we report that mid-infrared modulation (MIMO) at an intensity of 70 mW/cm2 promotes collagen production in human or mouse skin in vivo without generating excessive heat. We found that protein levels of the collagen- degrading endopeptidase, MMP-1, were decreased in the skin of mice following MIMO treatment, whereas the collagen synthesis-related factors, TGF-{beta}, HSP47, and HSP70, were all increased. In addition, MIMO stimulated collagen secretion in human dermal fibroblasts in vitro. This work demonstrates that MIMO is an effective, non-invasive, and painless intervention for in vivo enhancement of collagen production in the skin. One Sentence SummaryMid-infrared modulation promotes collagen production

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Wang, Z., Zhu, J., Wang, Y., Chen, S., Xu, S., Li, Y., Hu, T., Wang, X., Ji, R., Li, S. C., Yang, Y., Jia, H., Chen, X., Fan, X., Ge, L., Zhang, J.. 2024-03-29. Non-invasive and painless mid-infrared modulation increases collagen in human and mouse skin. https://doi.org/10.1101/2024.03.28.587170

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