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bioRxiv · 10.1101/2024.03.28.587165

Plant Cleavage Factor I complex is essential for precise cleavage and polyadenylation site determination

Abstract

Cleavage factor I (CFI) is a four-subunit protein complex of the pre-mRNA 3 end processing machinery in eukaryotes. In Arabidopsis, AtCFI25a, AtCFI25b, AtCFI59, and AtCFI68 have been identified as potential components of AtCFI, in silico. Here, we show that the AtCFI25a, AtCFI59, and AtCFI68 proteins each pulled down all components of the CFI, confirming that these subunits form the plant CFI complex. Furthermore, either AtCFI59 or AtCFI68 was essential for nuclear localization of the smallest subunit, AtCFI25a. Mutants with single loss-of-function for AtCFI59 or AtCFI68 showed no obvious morphological defects compared to wild-type plants, while the double mutant displayed pleiotropic morphological defects, identical to those previously reported for AtCFI25a loss-of-function plants. Moreover, these morphological defects correlated with alterations in the usage of 3 UTR cleavage and polyadenylation sites. atcfi25a, atcfi25a atcfi25b and atcfi59 atcfi68 double mutants showed widespread changes in the choice of cleavage and polyadenylation sites. In most cases, more proximal cleavage and polyadenylation sites were used, leading to shorter 3 UTRs. In particular, genes involved in light intensity, light harvesting, photosynthesis and cold responses showed significant dependence on AtCFI function. Furthermore, transcripts coding for AtCFI subunits showed altered 3 end processing in these mutants, suggesting self-regulation function of AtCFI in plants.

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BibTeXRIS

Szewc, L., Zhang, X., Bajczyk, M., Bielewicz, D., Zimna, M., Yura, K., Mariko Kato, M., Nomoto, M., Garcia-Leon, M., Rubio, V., Tada, Y., Furumoto, T., Aoyama, T., Szweykowska-Kulinska, Z., Staiger, D., Jarmolowski, A., Tsuge, T.. 2024-03-28. Plant Cleavage Factor I complex is essential for precise cleavage and polyadenylation site determination. https://doi.org/10.1101/2024.03.28.587165

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