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bioRxiv · 10.1101/2024.03.25.586530

A multicellular developmental program in a close animal relative

Olivetta, M.·Bhickta, C.·Chiaruttini, N.·Burns, J. A.·Dudin, O.
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Abstract

All animals develop from a single-celled zygote into a complex multicellular organism through a series of precisely orchestrated processes. Despite the remarkable conservation of early embryogenesis across animals, the evolutionary origins of this process remain elusive. By combining time-resolved imaging and transcriptomic profiling, we show that single cells of the ichthyosporean Chromosphaera perkinsii - a close relative that diverged from animals approximately 1 billion years ago - undergo symmetry breaking and develop through cleavage divisions to produce a prolonged multicellular colony with distinct co-existing cell types. Our findings about the autonomous developmental program of C. perkinsii, hint that such animal-like multicellular development is either much older than previously thought or evolved convergently in ichthyosporeans. One-Sentence SummaryThe ichthyosporean C. perkinsii develops via symmetry breaking, cleavage divisions, and forms spatially-organized colonies with distinct cell types.

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Olivetta, M., Bhickta, C., Chiaruttini, N., Burns, J. A., Dudin, O.. 2024-03-25. A multicellular developmental program in a close animal relative. https://doi.org/10.1101/2024.03.25.586530

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