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bioRxiv · 10.1101/2024.03.10.584310

Transcriptome analysis reveals a novel DNA element that may interact with chromatin-associated proteins in Plasmodium berghei during erythrocytic development

Abstract

BackgroundThe life cycle of Plasmodium parasites is intricate and multistage, alternating between dynamic environments. Temporal regulation of transcription by stage-specific transcription factor binding at particular regulatory regions within gene promoters facilitates its progression. As a result, each new developmental stage is endowed with its unique gene sets, whose just-in-time expression enables the parasite to completely adapt to the necessary circumstances. Our understanding of these transcriptome-level regulatory processes is limited, and more so, a thorough examination of the entire life cycle in the experimentally tractable rodent model organism P. berghei is lacking. ResultsWe performed a genome-wide analysis of RNA-Seq data from different developmental stages of P. berghei. Integrated data from the human malaria parasites P. falciparum and P. vivax demonstrated that Plasmodium parasites have a unique transcriptional signature. We identified the sets of genes differentially expressed at each stage, clustered them based on similarities of their expression profiles, and predicted the regulatory motifs governing their expression. We interpreted the motifs using known binding sites for established eukaryotic transcription factors, including those of the ApiAP2s, and identified eight potentially novel motifs. Additionally, we expanded the annotation of another motif--AGGTAA--found in genes exclusive to erythrocytic development and identified members of the PfMORC and GCN5 complexes among its possible interacting proteins. ConclusionThis study provides new insights into gene usage and its regulation during P. berghei development.

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BibTeXRIS

Okafor, A., Adam, Y., Brors, B., Adebiyi, E.. 2024-03-13. Transcriptome analysis reveals a novel DNA element that may interact with chromatin-associated proteins in Plasmodium berghei during erythrocytic development. https://doi.org/10.1101/2024.03.10.584310

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