Virological traits of the SARS-CoV-2 BA.2.87.1 lineage

Zhang, L.; Dopfer-Jablonka, A.; Nehlmeier, I.; Kempf, A.; Graichen, L.; Calderon Hampel, N.; Cossmann, A.; Stankov, M. V.; Morillas Ramos, G.; Schulz, S. R.; Jaeck, H.-M.; Behrens, G. M. N.; Poehlmann, S.; Hoffmann, M.

doi:10.1101/2024.02.27.582254

bioRxiv · 10.1101/2024.02.27.582254

Virological traits of the SARS-CoV-2 BA.2.87.1 lineage

Zhang, L.·Dopfer-Jablonka, A.·Nehlmeier, I.·Kempf, A.·Graichen, L.·Calderon Hampel, N.·Cossmann, A.·Stankov, M. V.·Morillas Ramos, G.·Schulz, S. R.·Jaeck, H.-M.·Behrens, G. M. N.·Poehlmann, S.·Hoffmann, M.

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Abstract

The highly mutated SARS-CoV-2 BA.2.87.1 lineage was recently detected in South Africa, but its transmissibility is unknown. Here, we report that BA.2.87.1 efficiently enters human cells but is more sensitive to antibody-mediated neutralization than the currently dominating JN.1 variant. Acquisition of adaptive mutations might thus be needed for high transmissibility.

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Zhang, L., Dopfer-Jablonka, A., Nehlmeier, I., Kempf, A., Graichen, L., Calderon Hampel, N., Cossmann, A., Stankov, M. V., Morillas Ramos, G., Schulz, S. R., Jaeck, H.-M., Behrens, G. M. N., Poehlmann, S., Hoffmann, M.. 2024-02-28. Virological traits of the SARS-CoV-2 BA.2.87.1 lineage. https://doi.org/10.1101/2024.02.27.582254

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