Striatal Dopamine Can Enhance Learning, Both Fast and Slow, and Also Make it Cheaper

Westbrook, A.; van den Bosch, R.; Hofmans, L.; Papadopetraki, D.; Maatta, J. I.; Collins, A. G. E.; Frank, M. J.; Cools, R.

doi:10.1101/2024.02.14.580392

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bioRxiv · 10.1101/2024.02.14.580392

Striatal Dopamine Can Enhance Learning, Both Fast and Slow, and Also Make it Cheaper

Westbrook, A.·van den Bosch, R.·Hofmans, L.·Papadopetraki, D.·Maatta, J. I.·Collins, A. G. E.·Frank, M. J.·Cools, R.

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Abstract

Associations can be learned incrementally, via reinforcement learning (RL), or stored instantly in working memory (WM). While WM is fast, it is also capacity-limited and effortful. Striatal dopamine may promote RL plasticity, and WM, by facilitating updating and effort exertion. Yet, prior studies have failed to distinguish between dopamines effects on RL versus WM. N = 100 participants completed a paradigm isolating these systems in a double-blind study measuring dopamine synthesis with [18F]-FDOPA imaging and manipulating dopamine with methylphenidate and sulpiride. Learning is enhanced among high synthesis capacity individuals and by methylphenidate, but impaired by sulpiride. Methylphenidate also blunts effort cost learning. Computational modeling reveals that individuals with high dopamine synthesis rely more on WM, while methylphenidate boosts their RL rates. The D2 antagonist sulpiride reduces accuracy due to diminished WM involvement and faster WM decay. We conclude that dopamine enhances both slow RL, and fast WM, by promoting plasticity and reducing effort sensitivity. These results also highlight the need to control for dopamines effects on WM when testing its effects on RL.

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Westbrook, A., van den Bosch, R., Hofmans, L., Papadopetraki, D., Maatta, J. I., Collins, A. G. E., Frank, M. J., Cools, R.. 2024-02-17. Striatal Dopamine Can Enhance Learning, Both Fast and Slow, and Also Make it Cheaper. https://doi.org/10.1101/2024.02.14.580392

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